{"product_id":"abm218832","title":"Human Protein Phosphatase, Mg2+, Mn2+ Dependent 1D, PPM1D ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eInvolved in the negative regulation of p53 expression (PubMed: 23242139). Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins (PubMed: 15870257, PubMed: 16311512). Mediates MAPK14 dephosphorylation and inactivation (PubMed: 21283629). Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity (By similarity).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57661597122900,"sku":"ABM218832","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57661597155668,"sku":"ABM218833","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-1c44192ded29e35118fd6d9ecdcb55bb15ec6a325f4ef7fd0078321b68fa869a.jpg?v=1792159238","url":"https:\/\/www.abmium.com\/fr\/products\/abm218832","provider":"ABMIUM","version":"1.0","type":"link"}