{"product_id":"abm218724","title":"Human Ras Association Domain-containing Protein 1, RASSF1 ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003ePotential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3\/MST2 and STK4\/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1\/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57661990076756,"sku":"ABM218724","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57661990109524,"sku":"ABM218725","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-8785f2497360b6e7f7782e473cdaff2536a93c41ef102fa9d4eaf6b66d08198d.jpg?v=1792159230","url":"https:\/\/www.abmium.com\/fr\/products\/abm218724","provider":"ABMIUM","version":"1.0","type":"link"}