{"product_id":"abm217784","title":"Human Small Ubiquitin-related Modifier 2, SUMO2 ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eUbiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2, CBX4 or ZNF451 (PubMed: 26524494). This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (PubMed: 18408734, PubMed: 18538659, PubMed: 21965678, PubMed: 9556629). Plays a role in the regulation of sumoylation status of SETX (PubMed: 24105744).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57661839802708,"sku":"ABM217784","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57661839835476,"sku":"ABM217785","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-4dd28e93e05ab6483d2e0dab3bfdc7e6cd689a512a6cb7b942918eecc0303857.jpg?v=1792159215","url":"https:\/\/www.abmium.com\/fr\/products\/abm217784","provider":"ABMIUM","version":"1.0","type":"link"}