{"product_id":"abm217580","title":"Human Ras-related Protein Rab-10, RAB10 ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThe small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed: 21248164). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed: 21248164). That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane (PubMed: 21248164). Regulates, for instance, SLC2A4\/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane (By similarity). In parallel, it regulates the transport of TLR4, a toll-like receptor to the plasma membrane and therefore may be important for innate immune response (By similarity). Plays also a specific role in asymmetric protein transport to the plasma membrane (PubMed: 16641372). In neurons, it is involved in axonogenesis through regulation of vesicular membrane trafficking toward the axonal plasma membrane (By similarity). In epithelial cells, it regulates transport from the Golgi to the basolateral membrane (PubMed: 16641372). May play a role in the basolateral recycling pathway and in phagosome maturation (By similarity). May play a role in endoplasmic reticulum dynamics and morphology controlling tubulation along microtubules and tubules fusion (PubMed: 23263280). Together with LRRK2, RAB8A, and RILPL1, it regulates ciliogenesis (PubMed: 30398148). When phosphorylated by LRRK2 on Thr-73, binds RILPL1 and inhibits ciliogenesis (PubMed: 30398148). (Microbial infection) Upon Legionella pneumophila infection promotes endoplasmic reticulum recruitment and bacterial replication. Plays a role in remodeling the Legionella-containing vacuole (LCV) into an endoplasmic reticulum-like vacuole.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57661637099860,"sku":"ABM217580","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57661637132628,"sku":"ABM217581","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-0b8024902eb0fb49c6c93542750094b48fa59d1ff6f7520e3ee4656b0650a9e2.jpg?v=1792159249","url":"https:\/\/www.abmium.com\/fr\/products\/abm217580","provider":"ABMIUM","version":"1.0","type":"link"}