{"product_id":"abm217408","title":"Human Pro-nerve Growth Factor, PRONGF ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eNerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems (PubMed: 14976160, PubMed: 20978020). Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (PubMed: 20978020) (Probable). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and\/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro) (By similarity). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI (PubMed: 20164177). Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer. The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form (By similarity).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57661968187732,"sku":"ABM217408","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57661968220500,"sku":"ABM217409","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-77596e2dfdf72b68c765d5ac867d843d5c56c24f85c3997a690899f05ccb3282.jpg?v=1792159237","url":"https:\/\/www.abmium.com\/fr\/products\/abm217408","provider":"ABMIUM","version":"1.0","type":"link"}