{"product_id":"abm216708","title":"Human Insulin-Degrading Enzyme, IDE ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003ePlays a role in the cellular breakdown of insulin, APP Peptides, IAPP Peptides, natriuretic Peptides, glucagon, bradykinin, kallidin, and other Peptides, and thereby plays a role in intercellular Peptide signaling (PubMed: 2293021, PubMed: 10684867, PubMed: 26968463, PubMed: 17051221, PubMed: 17613531, PubMed: 18986166, PubMed: 19321446, PubMed: 23922390, PubMed: 24847884, PubMed: 26394692, PubMed: 29596046, PubMed: 21098034). Substrate binding induces important conformation changes, making it possible to bind and degrade larger substrates, such as insulin (PubMed: 23922390, PubMed: 26394692, PubMed: 29596046). Contributes to the regulation of Peptide hormone signaling cascades and regulation of blood glucose homeostasis via its role in the degradation of insulin, glucagon and IAPP (By similarity). Plays a role in the degradation and clearance of APP-derived amyloidogenic Peptides that are secreted by neurons and microglia (PubMed: 9830016, PubMed: 26394692) (Probable). Degrades the natriuretic Peptides ANP, BNP and CNP, inactivating their ability to raise intracellular cGMP (PubMed: 21098034). Also degrades an aberrant frameshifted 40-residue form of NPPA (fsNPPA) which is associated with familial atrial fibrillation in heterozygous patients (PubMed: 21098034). Involved in antigen processing. Produces both the N terminus and the C terminus of MAGEA3-derived antigenic Peptide (EVDPIGHLY) that is presented to cytotoxic T lymphocytes by MHC class I. (Microbial infection) The membrane-associated isoform acts as an entry receptor for varicella-zoster virus (VZV).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57661968580948,"sku":"ABM216708","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57661968613716,"sku":"ABM216709","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-ba8369a823be142db5a559cdd651d12dc10f4650a602ff11077a7b3d8bd9e384.jpg?v=1792159237","url":"https:\/\/www.abmium.com\/fr\/products\/abm216708","provider":"ABMIUM","version":"1.0","type":"link"}