{"product_id":"abm216370","title":"Human Ephrin-A1, EFNA1 ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eCell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57661696016724,"sku":"ABM216370","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57661696049492,"sku":"ABM216371","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-8c5f3544f3ab4b5de876068a237c197b06341e21e9422d23a9daa6ca1065f2d1.jpg?v=1792159212","url":"https:\/\/www.abmium.com\/fr\/products\/abm216370","provider":"ABMIUM","version":"1.0","type":"link"}