{"product_id":"abm215758","title":"Human Caspase 3, CASP3 ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eInvolved in the activation cascade of caspases responsible for apoptosis execution (PubMed: 7596430). At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond (PubMed: 7774019). Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9 (PubMed: 7596430). Involved in the cleavage of huntingtin (PubMed: 8696339). Triggers cell adhesion in sympathetic neurons through RET cleavage (PubMed: 21357690). Cleaves and inhibits serine\/threonine-protein kinase AKT1 in response to oxidative stress (PubMed: 23152800).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57661713613140,"sku":"ABM215758","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57661713645908,"sku":"ABM215759","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-9fc09765f331b02721dcdff16154b8ce339810cbefa5a36673a7011cd22e44b9.jpg?v=1792159217","url":"https:\/\/www.abmium.com\/fr\/products\/abm215758","provider":"ABMIUM","version":"1.0","type":"link"}