{"product_id":"abm215266","title":"Human Serine, Threonine-protein Kinase Ulk1, ULK1 ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eSerine\/threonine-protein kinase involved in autophagy in response to starvation (PubMed: 18936157, PubMed: 21460634, PubMed: 21795849, PubMed: 25040165). Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes (PubMed: 18936157, PubMed: 21460634, PubMed: 21795849, PubMed: 25040165). Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR (PubMed: 21795849). Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity (PubMed: 21460634). May phosphorylate ATG13\/KIAA0652 and RPTOR; however such data need additional evidences (PubMed: 18936157). Plays a role early in neuronal differentiation and is required for granule cell axon formation (PubMed: 11146101). May also phosphorylate SESN2 and SQSTM1 to regulate autophagy (PubMed: 25040165). Phosphorylates FLCN, promoting autophagy (PubMed: 25126726).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57661834428756,"sku":"ABM215266","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57661834461524,"sku":"ABM215267","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-842bc10af25d7407ae3d0d7aa5a40f6df044af242464bac0e067a78c34fdc4d5.jpg?v=1792159239","url":"https:\/\/www.abmium.com\/fr\/products\/abm215266","provider":"ABMIUM","version":"1.0","type":"link"}