{"product_id":"abm214724","title":"Human Oxysterol-binding Protein-related Protein 3, OSBPL3 ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003ePhosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed: 16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed: 25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed: 18270267, PubMed: 25447204). With VAPA, may regulate ER morphology (PubMed: 16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed: 18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 (PubMed: 16143324). Also binds 25-hydroxycholesterol and cholesterol (PubMed: 17428193).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57661905174868,"sku":"ABM214724","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57661905207636,"sku":"ABM214725","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-e3cc930e4ff817933991885961a3b59a4061800bbdb32b9bf2f8e77e1ab52f43.jpg?v=1792159248","url":"https:\/\/www.abmium.com\/fr\/products\/abm214724","provider":"ABMIUM","version":"1.0","type":"link"}