{"product_id":"abm214684","title":"Human Programmed Cell Death Protein 1, PDCD1 ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eInhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self (PubMed: 21276005). Delivers inhibitory signals upon binding to ligands CD274\/PDCD1L1 and CD273\/PDCD1LG2 (PubMed: 21276005). Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (By similarity). Suppresses T-cell activation through the recruitment of PTPN11\/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11\/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ\/PKCtheta and CD247\/CD3zeta (By similarity). The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival (PubMed: 28951311). The interaction with CD274\/PDCD1L1 inhibits cytotoxic T lymphocytes (CTLs) effector function (PubMed: 28951311). The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy (PubMed: 22658127, PubMed: 25034862, PubMed: 25399552).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57661873619284,"sku":"ABM214684","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57661873652052,"sku":"ABM214685","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-121b38607de805ebcc21a35bebeacc244a65ecc18630ab093afaa3ef1986fb1a.jpg?v=1792159245","url":"https:\/\/www.abmium.com\/fr\/products\/abm214684","provider":"ABMIUM","version":"1.0","type":"link"}