{"product_id":"abm214590","title":"Human Nuclear Factor Erythroid 2-related Factor 2, NRF2 ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eTranscription factor that plays a key role in the response to oxidative stress: binds to antioxidant response (ARE) elements present in the promoter region of many cytoprotective genes, such as phase 2 detoxifying enzymes, and promotes their expression, thereby neutralizing reactive electrophiles (PubMed: 11035812, PubMed: 19489739, PubMed: 29018201, PubMed: 31398338). In normal conditions, ubiquitinated and degraded in the cytoplasm by the BCR(KEAP1) complex (PubMed: 11035812, PubMed: 15601839, PubMed: 29018201). In response to oxidative stress, electrophile metabolites inhibit activity of the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2\/NRF2, heterodimerization with one of the small Maf proteins and binding to ARE elements of cytoprotective target genes (PubMed: 19489739, PubMed: 29590092). The NFE2L2\/NRF2 pathway is also activated in response to selective autophagy: autophagy promotes interaction between KEAP1 and SQSTM1\/p62 and subsequent inactivation of the BCR(KEAP1) complex, leading to NFE2L2\/NRF2 nuclear accumulation and expression of cytoprotective genes (PubMed: 20452972). May also be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region (PubMed: 7937919).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57661800972628,"sku":"ABM214590","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57661801005396,"sku":"ABM214591","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-556c49c836ed41fb2d1bc0293cd28e0aca53aa06dcb33364dc6744de49b4c0d6.jpg?v=1792159238","url":"https:\/\/www.abmium.com\/fr\/products\/abm214590","provider":"ABMIUM","version":"1.0","type":"link"}