{"product_id":"abm214164","title":"Human Carbohydrate Sulfotransferase 4, CHST4 ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eSulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within mucin-associated glycans that ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X on receptors SPN\/CD43, GLYCAM1 and MADCAM1. Also involved in biosynthesis of SELL ligand recognized by MECA-79 antibody. Plays a central role in lymphocyte trafficking during chronic inflammation. Has a catalytic preference for core 2-branched mucin-type O-glycans. Can use GlcNAcbeta1-6[Galbeta1-3]GalNAc-pNP (core 2), GlcNAcbeta1-6ManOMe and GlcNAcbeta1-2Man oligosaccharide structures as acceptors. Has also activity toward core 3 of GlcNAcbeta1-3GalNAc-pNP. Its substrate specificity may be influenced by its subcellular location.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57661958750548,"sku":"ABM214164","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57661958783316,"sku":"ABM214165","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-b7af25ab8d081e7453dca931c73fb6387ae5e2cbf988cbbb8d95732584911035.jpg?v=1792159206","url":"https:\/\/www.abmium.com\/fr\/products\/abm214164","provider":"ABMIUM","version":"1.0","type":"link"}