{"product_id":"abm213366","title":"Mouse Suppressors of Cytokine Signaling 1, SOCS-1 ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eSOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK\/STAT pathway (PubMed:15522878). Through binding to JAKs and IFNGR1, inhibits their kinase activity (PubMed:9202125). In vitro, also suppresses Tec protein-tyrosine activity (By similarity). Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF) (PubMed:9202125). Regulates interferon-gamma (IFNG) mediated sensory neuron survival. Probable substrate recognition component of an ECS (Elongin BC-CUL2\/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2 (By similarity). SOCS1 appears to be a negative regulator in IGF1R signaling pathway (By similarity).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57661870047572,"sku":"ABM213366","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57661870080340,"sku":"ABM213367","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-cadf3087398573e34e3a8df4cbfa7730bfa2778f18ee7c336f5fb07ab99afb0c.jpg?v=1792159246","url":"https:\/\/www.abmium.com\/fr\/products\/abm213366","provider":"ABMIUM","version":"1.0","type":"link"}