{"product_id":"abm212682","title":"Human Anti-oxidized Low Density Lipoprotein Antibody, OLAB ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eReceptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57661859856724,"sku":"ABM212682","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57661859889492,"sku":"ABM212683","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-38a27245781ca8261f952d8b80766a5cf77e93df8a0e05e7b8eba279b8d03676.jpg?v=1792159252","url":"https:\/\/www.abmium.com\/fr\/products\/abm212682","provider":"ABMIUM","version":"1.0","type":"link"}