{"product_id":"abm212514","title":"Rat Steroid 17-alpha-hydroxylase, CYP17A1 ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eA cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, dehydroepiandrosterone (DHEA) and androstenedione. Has 16-alpha hydroxylase activity. Catalyzes 16-alpha hydroxylation of 17-alpha hydroxy pregnenolone, followed by the cleavage of the C17-C20 bond to form 16-alpha-hydroxy DHEA. Also 16-alpha hydroxylates androgens, relevant for estriol synthesis. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57661706174804,"sku":"ABM212514","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57661706207572,"sku":"ABM212515","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-e8b307f0ec4a87fb0b1a669030023fc92602845958ae8f90d9a0728de504be3b.jpg?v=1792159239","url":"https:\/\/www.abmium.com\/fr\/products\/abm212514","provider":"ABMIUM","version":"1.0","type":"link"}