{"product_id":"abm212120","title":"Mouse Interleukin-36 Beta, IL1F8 ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eCytokine that binds to and signals through the IL1RL2\/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial Peptides including beta-defensin 4 and beta-defensin 103 as well as a number of matrix metalloproteases (By similarity). Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. Induces the production of proinflammatory cytokines in bone marrow-derived dendritic cells (BMDCs), including IL-12, Il-1 beta, IL-6, TNF-alpha and IL-23, and activates p38 MAPK phosphorylation in BMDCs. Involved in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II. Induces the production of IFN-gamma, IL-4 and IL-17 by T-helper 1 (Th1) cells, cultured CD4(+) T-cells and splenocytes.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57661829906772,"sku":"ABM212120","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57661829939540,"sku":"ABM212121","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-526690ac2d8e2eb6283cdd390cee5c14b121f34efa241e000690a81c7f5c9f27.jpg?v=1792159207","url":"https:\/\/www.abmium.com\/fr\/products\/abm212120","provider":"ABMIUM","version":"1.0","type":"link"}