{"product_id":"abm211896","title":"Mouse Histone Deacetylase 6, HDAC6 ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eResponsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed: 9891014). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (PubMed: 9891014). Histone deacetylases act via the formation of large multiprotein complexes (PubMed: 9891014). In addition to histones, deacetylates other proteins: plays a central role in microtubule-dependent cell motility by mediating deacetylation of tubulin (PubMed: 19893491). Promotes deacetylation of CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy (By similarity). In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome (By similarity). Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy (PubMed: 22819792).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57661686120788,"sku":"ABM211896","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57661686153556,"sku":"ABM211897","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-7bb728db7a0cac06114123e889859d85752aa4daeb19d53684b27bddcb397857.jpg?v=1792159246","url":"https:\/\/www.abmium.com\/fr\/products\/abm211896","provider":"ABMIUM","version":"1.0","type":"link"}