{"product_id":"abm209572","title":"Mouse Epidermal Growth Factor Receptor, EGFR ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eReceptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed: 8404850). Known ligands include EGF, TGFA\/TGF-alpha, AREG, epigen\/EPGN, BTC\/betacellulin, epiregulin\/EREG and HBEGF\/heparin-binding EGF. Ligand binding triggers receptor homo- and\/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1\/beta-catenin (By similarity). Positively regulates cell migration via interaction with CCDC88A\/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (By similarity). Plays a role in enhancing learning and memory performance (PubMed: 20639532).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57661958619476,"sku":"ABM209572","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57661958652244,"sku":"ABM209573","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-3c7ab442bfbb018820af8a7514bbbd781758d94d3f23a414cb93541452ba326e.jpg?v=1792159220","url":"https:\/\/www.abmium.com\/fr\/products\/abm209572","provider":"ABMIUM","version":"1.0","type":"link"}