{"product_id":"abm209556","title":"Human Presenilin 2, PS-2 ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eProbable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak Channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis (PubMed: 16959576). Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria (PubMed: 21285369).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57661944267092,"sku":"ABM209556","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57661944299860,"sku":"ABM209557","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-420081d5f307c86c3e3019c7a046fdf841447f7d6356e2714c1e1e0c5f440ec1.jpg?v=1792159219","url":"https:\/\/www.abmium.com\/fr\/products\/abm209556","provider":"ABMIUM","version":"1.0","type":"link"}