{"product_id":"abm209426","title":"Rat Beclin 1, BECN1 ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003ePlays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis. May play a role in antiviral host defense (By similarity). Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57661826203988,"sku":"ABM209426","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57661826236756,"sku":"ABM209427","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-271a50c12d772a3fd75652f0ed966376627020515640ab0e00e1d540d3d0ccca.jpg?v=1792159209","url":"https:\/\/www.abmium.com\/fr\/products\/abm209426","provider":"ABMIUM","version":"1.0","type":"link"}