{"product_id":"abm208198","title":"Rat Bone Morphogenetic Protein 4, BMP-4 ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eGrowth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including neurogenesis, vascular development, angiogenesis and osteogenesis (By similarity). Acts in concert with PTHLH\/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1\/5\/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Can also signal through non-canonical BMP pathways such as ERK\/MAP kinase, PI3K\/Akt, or SRC cascades. For example, induces SRC phosphorylation which, in turn, activates VEGFR2, leading to an angiogenic response (By similarity).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57661837246804,"sku":"ABM208198","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57661837279572,"sku":"ABM208199","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-58a71e5d08e73b920cc777c2f440c1be8ec186b05bc434a1d1639c12cdc8c177.jpg?v=1792159137","url":"https:\/\/www.abmium.com\/fr\/products\/abm208198","provider":"ABMIUM","version":"1.0","type":"link"}