{"product_id":"abm207852","title":"Mouse Intelectin-1, ITLN1\/OMENTIN ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eAdapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery (PubMed: 1006$458.00|$300.003). Acts as guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2\/3 complex (By similarity). Plays a role in the assembly and maturation of clathrin-coated vesicles (By similarity). Recruits FCHSD2 to clathrin-coated pits (By similarity). Involved in endocytosis of activated EGFR, and probably also other growth factor receptors (PubMed: 16914641). Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2 (By similarity). Promotes ubiquitination and subsequent degradation of EGFR, and thereby contributes to the down-regulation of EGFR-dependent signaling pathways (PubMed: 16914641). In chromaffin cells, required for normal exocytosis of catecholamines (PubMed: 18676989). Required for rapid replenishment of release-ready synaptic vesicles at presynaptic active zones (PubMed: 23633571). Inhibits ARHGAP31 activity toward RAC1 (By similarity). [Isoform 1]: Plays a role in synaptic vesicle endocytosis in brain neurons.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57661472637268,"sku":"ABM207852","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57661472670036,"sku":"ABM207853","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-fcc13082f103c3a2d7f4cd2746eb2bd34f8a0baef1420cfc5b314a845e2b8b4d.jpg?v=1792159112","url":"https:\/\/www.abmium.com\/fr\/products\/abm207852","provider":"ABMIUM","version":"1.0","type":"link"}