{"product_id":"abm204919","title":"OCT-4 Monoclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eOct4: octamer-binding transcription factor-4 (Oct-4, Otf-4) and Oct-3\/4, also known as POU5F1(POU class 5 homeobox 1), octamerbinding transcription factor-3 (Oct-3, Otf-3), modulates embryonic stem (ES) cell populations by influencing lineage commitment. Entrez Protein NP_002692. Oct-3\/4 sustains stem-cell selfrenewal and differentiation pathways. Transcription factors containing the POU homeodomain regulate tissue-specific gene expression in lymphoid and pituitary differentiation and in early mammalian development. Oct-3\/4 is capable of inducing rapid proliferation and tumorigenic properties of ES cells through activation of the UTF1 gene. In humans, two Oct-3\/4 isoforms contribute to influencing the undifferentiated phenotype of ES cells. Oct-3\/4 pseudogenes localizing to human chromosomes 10 and 8 are reported to be transcribed in certain cancer cell lines and tissues.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"100μL","offer_id":57661118120276,"sku":"ABM204919","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"50μL","offer_id":57661118153044,"sku":"ABM204920","price":141.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-a65875d5ea6e4c31f66aab28d1dc55e93ed92ba0ffc43fe039ce3569e5b2c717.jpg?v=1792159098","url":"https:\/\/www.abmium.com\/fr\/products\/abm204919","provider":"ABMIUM","version":"1.0","type":"link"}