{"product_id":"abm203109","title":"ITGA5 Monoclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThe product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. Integrin alpha 5 is a heterodimer that associates noncovalently with CD29\/integrin beta 1 subunit to form the alpha-5-beta-1 very late antigen (VLA-5) complex. VLA-5 is a fibronectin receptor that is expressed on thymocytes, T-cells, monocytes and platelets. It is also found on very early B-cells and activated B-cells. VLA-5-mediated binding to fibronectin sends a costimulatory signal to T-cells and enhances Fc-gamma-R- and complement receptor-mediated phago-cytosis. It is also involved in monocyte migration into extracellular tissues.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"100μL","offer_id":57661080469844,"sku":"ABM203109","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"50μL","offer_id":57661080502612,"sku":"ABM203110","price":141.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-98cdd32914ad714c38839c31a3c75fe8c8cabac2b96d19ca42d78c7bd5c7cb38.jpg?v=1792159110","url":"https:\/\/www.abmium.com\/fr\/products\/abm203109","provider":"ABMIUM","version":"1.0","type":"link"}