{"product_id":"abm201489","title":"ApoB Monoclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThis gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA-\u0026gt;UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"100μL","offer_id":57661039346004,"sku":"ABM201489","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"50μL","offer_id":57661039378772,"sku":"ABM201490","price":141.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-21a24629c5a8f3979bc1318be8b1f68e68b11f99286dede83889f5714ab23cc2.jpg?v=1792158983","url":"https:\/\/www.abmium.com\/fr\/products\/abm201489","provider":"ABMIUM","version":"1.0","type":"link"}