{"product_id":"abm200802","title":"ZAP-70 Monoclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThis gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"50ul","offer_id":57661081616724,"sku":"ABM200802","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"100ul","offer_id":57661081649492,"sku":"ABM200803","price":192.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-5ca30d850735e8b5ed4038ce2c74be67c078ff406abfe53cbb8b72dac1356827.jpg?v=1792158981","url":"https:\/\/www.abmium.com\/fr\/products\/abm200802","provider":"ABMIUM","version":"1.0","type":"link"}