{"product_id":"abm199378","title":"E2A Monoclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThis gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1|19), with PBX1), childhood leukemia (t(19|19), with TFPT) and acute leukemia (t(12|19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have bee\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"50ul","offer_id":57661440754004,"sku":"ABM199378","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"100ul","offer_id":57661440786772,"sku":"ABM199379","price":192.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-4ea40a0b7629055bcabd17431169466e22ec33c4c6942bb77b5b851bb59a4af6.jpg?v=1792158988","url":"https:\/\/www.abmium.com\/fr\/products\/abm199378","provider":"ABMIUM","version":"1.0","type":"link"}