{"product_id":"abm197477","title":"VHL(Phospho Ser68) Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eVon Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G\/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"100ul","offer_id":57660771500372,"sku":"ABM197477","price":176.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57660771533140,"sku":"ABM197478","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"20ul","offer_id":57660771565908,"sku":"ABM197479","price":69.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-1ea4c7287cbfdf5088445786c5a5187a69f59f2a2d1db38ede993084a9fd9773.jpg?v=1792241051","url":"https:\/\/www.abmium.com\/fr\/products\/abm197477","provider":"ABMIUM","version":"1.0","type":"link"}