{"product_id":"abm192749","title":"RIPK1 Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eCatalytic activity:ATP + a protein = ADP + a phosphoprotein.,Promotes apoptosis and activation of NF-kappa-B. Required for TNFRSF1A mediated activation of NF-kappa-B.,PTM:Autophosphorylated on serine and threonine residues.,PTM:Proteolytically cleaved by caspase-8 during TNF-induced apoptosis. Cleavage abolishes NF-kappa-B activation and enhances pro-apototic signaling through the TRADD-FADD interaction.,Belongs to the protein kinase superfamily. TKL Ser\/Thr protein kinase family.,Contains 1 death domain.,Contains 1 protein kinase domain.,subunit:Binds to the death domain of TNFRSF6 and TRADD. Is recruited by TRADD to TNFRSF1A in a TNF-dependent process. Binds RIPK3, UBCE7IP1 isoform 3 (ZIN), EGFR, IKBKG, TRAF1, TRAF2 and TRAF3. Interacts with BNLF1. Interacts with SQSTM1 upon TNF-alpha stimulation. May interacts with MAVS\/IPS1.,\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"100ul","offer_id":57660827140436,"sku":"ABM192749","price":176.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57660827173204,"sku":"ABM192750","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"20ul","offer_id":57660827205972,"sku":"ABM192751","price":69.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-1ea4c7287cbfdf5088445786c5a5187a69f59f2a2d1db38ede993084a9fd9773.jpg?v=1792241051","url":"https:\/\/www.abmium.com\/fr\/products\/abm192749","provider":"ABMIUM","version":"1.0","type":"link"}