{"product_id":"abm186902","title":"PDE11 Rabbit Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThe 3'|5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3'|5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"100ul","offer_id":57660862071124,"sku":"ABM186902","price":176.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57660862103892,"sku":"ABM186903","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"20ul","offer_id":57660862136660,"sku":"ABM186904","price":69.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-1c3b1fd67d03d4b2bce8b7a3d9da24522693b557148d663cd7761e63ef4ed7f2.jpg?v=1792158980","url":"https:\/\/www.abmium.com\/fr\/products\/abm186902","provider":"ABMIUM","version":"1.0","type":"link"}