{"product_id":"abm176254","title":"Sgo1 Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eShugoshin-like 1 encoded by SGOL1 is a member of the shugoshin family of proteins. This protein is thought to protect centromeric cohesin from cleavage during mitotic prophase by preventing phosphorylation of a cohesin subunit. Reduced expression of this gene leads to the premature loss of centromeric cohesion, mis-segregation of sister chromatids, and mitotic arrest. Evidence suggests that this protein also protects a small subset of cohesin found along the length of the chromosome arms during mitotic prophase. An isoform lacking exon 6 has been shown to play a role in the cohesion of centrioles (PMID: 16582621 and PMID: 18331714). Mutations in this gene have been associated with Chronic Atrial and Intestinal Dysrhythmia (CAID) syndrome, characterized by the co-occurrence of Sick Sinus Syndrome (SSS) and Chronic Intestinal Pseudo-obstruction (CIPO) within the first four decades of life (PMID: 25282101). Fibroblast cells from CAID patients exhibited both increased cell proliferation and higher rates of senescence. Pseudogenes of this gene have been found on chromosomes 1 and 7. Alternative splicing results in multiple transcript variants.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"20ul","offer_id":57660059910484,"sku":"ABM176254","price":69.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57660059943252,"sku":"ABM176255","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"100ul","offer_id":57660059976020,"sku":"ABM176256","price":176.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-3b7a97efff7259eebf51ec5259963c8d7bb784801e328853cc608d89f4fd1ce2.jpg?v=1792158853","url":"https:\/\/www.abmium.com\/fr\/products\/abm176254","provider":"ABMIUM","version":"1.0","type":"link"}