{"product_id":"abm174817","title":"RANKL Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThis gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT\/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B ly\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"20ul","offer_id":57659884863828,"sku":"ABM174817","price":69.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57659884896596,"sku":"ABM174818","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"100ul","offer_id":57659884929364,"sku":"ABM174819","price":176.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-ffbabe9141b99c7b5d3644b45fb1f79cf68430f2f5dcad8c5cf7599358598143.jpg?v=1792158838","url":"https:\/\/www.abmium.com\/fr\/products\/abm174817","provider":"ABMIUM","version":"1.0","type":"link"}