{"product_id":"abm173845","title":"PSMD12 Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThe 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP\/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PSMD12 encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 3. Alternatively spliced transcript variants encoding different isoforms have been found for PSMD12.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"20ul","offer_id":57660064923988,"sku":"ABM173845","price":69.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57660064956756,"sku":"ABM173846","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"100ul","offer_id":57660064989524,"sku":"ABM173847","price":176.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-b057498cf4739fd1a3340ccf9c6163bbc2ab97236e724d510ae2ecd7eb3c9c52.jpg?v=1792158837","url":"https:\/\/www.abmium.com\/fr\/products\/abm173845","provider":"ABMIUM","version":"1.0","type":"link"}