{"product_id":"abm173662","title":"Presenilin 1 Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eAlzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"20ul","offer_id":57659915862356,"sku":"ABM173662","price":69.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57659915895124,"sku":"ABM173663","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"100ul","offer_id":57659915927892,"sku":"ABM173664","price":176.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-fa96a54deede78e3ea0cb1b5d2cc7e0ec9104e1013d66df200f9cf3a3aeb54b7.jpg?v=1792158815","url":"https:\/\/www.abmium.com\/fr\/products\/abm173662","provider":"ABMIUM","version":"1.0","type":"link"}