{"product_id":"abm171889","title":"p40-phox Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThe protein encoded by NCF4 is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2\/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1\/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of neutrophil cytosolic factor 4 was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"20ul","offer_id":57660521513300,"sku":"ABM171889","price":69.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57660521546068,"sku":"ABM171890","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"100ul","offer_id":57660521578836,"sku":"ABM171891","price":176.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-6cc8ec57b93e743c85c06560373a1b61d10612b2f2ad71028e86b2f513c829f2.jpg?v=1792158912","url":"https:\/\/www.abmium.com\/fr\/products\/abm171889","provider":"ABMIUM","version":"1.0","type":"link"}