{"product_id":"abm166567","title":"LATS1\/2 Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eSerine\/threonine-protein kinase LATS1\/2 encoded by LATS1 is a putative serine\/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2\/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. Two protein-coding transcripts and one non-protein coding transcript have been found for this gene.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"20ul","offer_id":57660055781716,"sku":"ABM166567","price":69.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57660055814484,"sku":"ABM166568","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"100ul","offer_id":57660055847252,"sku":"ABM166569","price":176.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-de49b028ade3585778e52acd369a165cd6ca6a88e347c0cd82440d5f731c3053.jpg?v=1792158870","url":"https:\/\/www.abmium.com\/fr\/products\/abm166567","provider":"ABMIUM","version":"1.0","type":"link"}