{"product_id":"abm157336","title":"Cleaved-Caspase-1 p20 (N120) Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eCASP1 (caspase 1) encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. CASP1 was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. CASP1 has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"20ul","offer_id":57660290203988,"sku":"ABM157336","price":69.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57660290236756,"sku":"ABM157337","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"100ul","offer_id":57660290269524,"sku":"ABM157338","price":176.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-ae1d9bf14d9aff83cc6cde7fd56cc31a8dd0acbcb56a296c859021358e6e8fc6.jpg?v=1792157339","url":"https:\/\/www.abmium.com\/fr\/products\/abm157336","provider":"ABMIUM","version":"1.0","type":"link"}