{"product_id":"abm154596","title":"BRAF35 Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThe breast cancer susceptibility gene (BRCA1) localizes to chromosome 17q. Mutations within this gene account for approximately 45% of families with high incidence of breast cancer and at least 80% of families with increased incidence of both early-onset breast cancer and ovarian cancer. A second breast cancer susceptibility gene, BRCA2, located on chromosome 13q12-13, also confers a high incidence of breast cancer, but unlike BRCA1, BRCA2 does not confer a substantially elevated risk of ovarian cancer. The BRCA2-Associated Factor 35 (BRAF35) protein forms a complex with BRCA2, which associates with condensed chromatin during histone H3 phosphorylation. BRAF35 expression levels are highest in proliferating tissues and parallel BRCA2 expression patterns. The structure of BRAF35 includes a kinesin-like coiled coil domain and a nonspecific DNA binding HMG domain. The chromatin localization of BRAF35 and antibody microinjection studies indicate a role for the BRAF35\/BRCA2 complex in cell cycle regulation.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"20ul","offer_id":57660022718804,"sku":"ABM154596","price":69.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57660022751572,"sku":"ABM154597","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"100ul","offer_id":57660022784340,"sku":"ABM154598","price":176.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-90e61074252ff79539884daf156eaa94b069df29f96dea842de36cc6f5611e9d.jpg?v=1792157315","url":"https:\/\/www.abmium.com\/fr\/products\/abm154596","provider":"ABMIUM","version":"1.0","type":"link"}