{"product_id":"abm154431","title":"BLNK Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eBLNK encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein (B-cell linker)has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for BLNK.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"20ul","offer_id":57659899740500,"sku":"ABM154431","price":69.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57659899773268,"sku":"ABM154432","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"100ul","offer_id":57659899806036,"sku":"ABM154433","price":176.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-5817898bd5c484cfd5daf5c93aecb3dfa8b82d51f15b89a8f1c45692d3d417a9.jpg?v=1792157296","url":"https:\/\/www.abmium.com\/fr\/products\/abm154431","provider":"ABMIUM","version":"1.0","type":"link"}