{"product_id":"abm-148986-anti-human-mouse-rat-phospho-tau-ser396-antibody-b889","title":"Recombinant Anti-Human\/Mouse\/Rat Phospho-Tau (Ser396) Antibody [B889]","description":"\u003cp\u003e\u003cstrong\u003eRecombinant Phospho-Tau (Ser396) Monoclonal Antibody [B889]\u003c\/strong\u003e from Elabscience is a rabbit recombinant monoclonal antibody for research use only.\u003c\/p\u003e\n\u003ch3\u003eBackground\u003c\/h3\u003e\n\u003cp\u003eMAPT encodes microtubule-associated protein tau. Alternative splicing produces multiple tau isoforms whose expression varies with neuronal type and maturation. Tau is central to microtubule organisation in neurons, and altered MAPT function or phosphorylation is associated with several neurodegenerative disorders including Alzheimer’s disease, Pick’s disease, frontotemporal dementia, corticobasal degeneration and progressive supranuclear palsy. This antibody recognises tau phosphorylated around Ser396.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eProduct profile:\u003c\/strong\u003e Human, Mouse and Rat reactivity; Rabbit host; recombinant monoclonal; clone B889; IgG,κ; Unconjugated.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eApplication evidence:\u003c\/strong\u003e WB, IHC, IF\/ICC and ELISA. Elabscience reports Neuro-2a as a verified WB sample and human brain as a verified IHC sample. Recommended dilutions: WB 1:2000-1:10000; IHC 1:200-1:1000; IF 1:200-1:1000; ELISA 1:5000-1:20000.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eTechnical details:\u003c\/strong\u003e Immunogen: synthetic peptide corresponding to residues around Ser396 of human phospho-Tau; Protein A purified; 0.2 mg\/mL; calculated MW 79 kDa; observed 55-130 kDa; UniProt P10636.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStorage:\u003c\/strong\u003e Store at -20°C for up to 12 months and avoid repeated freeze\/thaw cycles. Shipped with an ice bag.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eResearch Use Only.\u003c\/strong\u003e\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"100uL \/ Unconjugated","offer_id":57449284239700,"sku":"ABM148986-1","price":190.4,"currency_code":"GBP","in_stock":true},{"title":"50uL \/ Unconjugated","offer_id":57449284272468,"sku":"ABM148986-2","price":125.6,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/upload-1791296007812.jpg?v=1791296010","url":"https:\/\/www.abmium.com\/fr\/products\/abm-148986-anti-human-mouse-rat-phospho-tau-ser396-antibody-b889","provider":"ABMIUM","version":"1.0","type":"link"}