{"product_id":"tribio-tasin-1-induces-apoptosis-in-cells-with-apc-truncations","title":"TASIN-1, Induces apoptosis in cells with APC truncations","description":"\u003cp\u003eSelectively induces apoptosis in cells with truncations in the adenomatous polyposis coli (APC) gene (but not normal cells or wild type cancer cells), an important multifunctional tumor suppressor gene. IC50 = 70nM for DLD1 cell line. It inhibited cancer cell growth in human tumor xenografts (DLD1 and HT29 tumors) and a genetically engineered mouse model (CPC;Apc) of colorectal cancer. TASIN-1 induces ER stress-dependent JNK activation with ROS production and AKT inhibition via cholesterol depletion\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57411080552788,"sku":"ABM148815-1","price":450.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57411080585556,"sku":"ABM148815-2","price":114.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI4890.png?v=1791105160","url":"https:\/\/www.abmium.com\/es\/products\/tribio-tasin-1-induces-apoptosis-in-cells-with-apc-truncations","provider":"ABMIUM","version":"1.0","type":"link"}