{"product_id":"tribio-talabostat-mesylate-pyroptosis-inducer-inflammasome-activator","title":"Talabostat mesylate, Pyroptosis inducer; Inflammasome activator","description":"\u003cp\u003eTalabostat mesylate is a non-selective inhibitor of the S9 family of serine proteases (IC50’s: DPPIV = \u0026lt;4nM, DPP8 = 4nM, DPP9 = 11nM, QPP = 310nM, FAP = 560nM, PEP = 390nM). Toxicity caused by DPP8\/9 inhibition observed with non-selective DPPIV inhibitors limits their use as a diabetes treatment. However, Talabostat displays potent antitumor effects dependent on an intact host immune response. It mediates tumor regression by accelerating the expansion of tumor-specific T cells. Additionally, DPP8\/9 inhibition by Talabostat activates the proprotein form of Caspase-1 leading to a proinflammatory form of cell death in monocytes and macrophages – pyroptosis. Pyroptosis induction by DPP8\/9 inhibition has been shown to be caused by activation of the inflammasome sensor protein Nlrp1b\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"10 MG","offer_id":57411079242068,"sku":"ABM148811-1","price":98.0,"currency_code":"GBP","in_stock":true},{"title":"50 MG","offer_id":57411079274836,"sku":"ABM148811-2","price":384.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI4005.png?v=1791105157","url":"https:\/\/www.abmium.com\/es\/products\/tribio-talabostat-mesylate-pyroptosis-inducer-inflammasome-activator","provider":"ABMIUM","version":"1.0","type":"link"}