{"product_id":"tribio-prt-4165-e3-ubiquitin-ligase-inhibitor","title":"PRT-4165, E3 Ubiquitin ligase inhibitor","description":"\u003cp\u003eInhibitor of Bmi1\/Ring1A, subunits of the polycomb repressive complex 1 (PRC1). Inhibits self-ubiquitination (IC50 = 3.9 μM) but does not increase cellular levels of either subunit. Blocks Bmi1\/Ring1A-mediated ubiquitination and drug-induced degradation of topoisomerase 2α. Inhibits H2A\/H2AX ubiquitination via blocking the E3 ubiquitin ligase activity of RNF2 and a Bmi1\/RNF2 complex. Blocks polycomb repressor complex (PRC) 1-mediated histone H2A ubiquitination in vitro and in vivo and as such represents a new tool for studying chromatin remodeling\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"10 MG","offer_id":57411055124820,"sku":"ABM148607-1","price":106.0,"currency_code":"GBP","in_stock":true},{"title":"50 MG","offer_id":57411055157588,"sku":"ABM148607-2","price":425.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI1478.png?v=1791104966","url":"https:\/\/www.abmium.com\/es\/products\/tribio-prt-4165-e3-ubiquitin-ligase-inhibitor","provider":"ABMIUM","version":"1.0","type":"link"}