{"product_id":"tribio-pit-1-ph-domain-antagonist","title":"PIT-1, PH Domain antagonist","description":"\u003cp\u003ePH domain antagonist. Specifically blocks the binding of PIP3 to the Akt pleckstrin homology domain (IC50 = 31 μM). Suppresses PI3K-PDK1-Akt-dependent phosphorylation. Induces apoptosis in PTEN-deficient U87mgglioblastoma cells (IC50 = 37 μM). Inhibiting the binding of PIP3 to effector PH domains is new point of intervention in the PI3K signaling network2\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"10 MG","offer_id":57410959999316,"sku":"ABM147559-1","price":57.0,"currency_code":"GBP","in_stock":true},{"title":"50 MG","offer_id":57410960032084,"sku":"ABM147559-2","price":196.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI1192.png?v=1791104183","url":"https:\/\/www.abmium.com\/es\/products\/tribio-pit-1-ph-domain-antagonist","provider":"ABMIUM","version":"1.0","type":"link"}