{"product_id":"tribio-iwp-4-wnt-inhibitor","title":"IWP-4, Wnt inhibitor","description":"\u003cp\u003ePotent Wnt pathway inhibitor (IC50 = 25 nM in cells that exhibit constitutive Wnt pathway activation) that targets Porcupine (a membrane-bound O-acyltransferase), preventing critical Wnt ligand palmitoylation. Also acts as an ATP-competitive inhibitor of mutant (M82F) Casein Kinase 1δ (IC50 = 142 nM). Inhibits growth and migration of cancer cell lines such as HT29, Panc1, and MDA-MB-2312,. Inhibits osteogenic differentiation. When used with CHIR-99021 (#MC-1279), induces cardiac differentiation by blocking expression of pluripotency markers and upregulating cardiac transcription factors\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57410909569364,"sku":"ABM147208-1","price":531.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57410909602132,"sku":"ABM147208-2","price":114.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI3370.png?v=1791103616","url":"https:\/\/www.abmium.com\/es\/products\/tribio-iwp-4-wnt-inhibitor","provider":"ABMIUM","version":"1.0","type":"link"}