{"product_id":"tribio-irinotecan-hcl-topoisomerase-i-inhibitor","title":"Irinotecan HCl, Topoisomerase I inhibitor","description":"\u003cp\u003eIrinotecan is a semi-synthetic derivative of camptothecin that is an FDA approved anticancer drug. It is a prodrug that is converted by tissue esterases to 7-ethyl-10-hydroxycamptothecin (SN-38), a potent inhibitor of DNA topoisomerase I. Although irinotecan is also a topoisomerase inhibitor, SN-38 is approximately 1000 times as potent in purified enzyme studies. In vitro cytotoxicity assays show much greater variability in potency between the two (2-2000 fold)\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"250 MG","offer_id":57410905243988,"sku":"ABM147194-1","price":392.0,"currency_code":"GBP","in_stock":true},{"title":"50 MG","offer_id":57410905276756,"sku":"ABM147194-2","price":98.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI2146.png?v=1791103606","url":"https:\/\/www.abmium.com\/es\/products\/tribio-irinotecan-hcl-topoisomerase-i-inhibitor","provider":"ABMIUM","version":"1.0","type":"link"}