{"product_id":"tribio-epacadostat-ido1-inhibitor","title":"Epacadostat, IDO1 inhibitor","description":"\u003cp\u003eEpacadostat is a potent (IC50 = 10nM) and selective inhibitor of indoleamine-2,3-dioxygenase 1 (IDO1) with no activity at IDO2 or TDO. It restored tryptophan levels and significantly impaired kynurenine generation in CT26 colon carcinoma (IC50 = 76 nM) and PAN02 pancreatic carcinoma (IC50 = 27 nM) cells. Epacadostat increases the number and activity of tumor-infiltrating lymphocytes as well as increasing the ratio of effector T cells to regulatory T cells. Because of these immune system enhancing properties, it is being investigated as a synergistic agent for use with other immuno-oncology agents such as anti-PD-1 and anti-CTL4 antibodies\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57410899149140,"sku":"ABM146986-1","price":294.0,"currency_code":"USD","in_stock":true},{"title":"5 MG","offer_id":57410899181908,"sku":"ABM146986-2","price":89.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI4499.png?v=1791103443","url":"https:\/\/www.abmium.com\/es\/products\/tribio-epacadostat-ido1-inhibitor","provider":"ABMIUM","version":"1.0","type":"link"}