{"product_id":"tribio-bosutinib-src-abl-kinase-inhibitor","title":"Bosutinib, Src\/Abl kinase inhibitor","description":"\u003cp\u003eBosutinib is an ATP-competitive dual Src\/Abl kinase inhibitor (IC50 = 1 nM). It potently inhibits the apoptosis-linked STE20 kinases but does not inhibit Kit or PDGFR. Bosutinib was found to inhibit 16 of 18 imatinib-resistant mutant forms of Bcr-Abl expressed in murine myeloid cell lines, but did not inhibit T315I and V299L mutants. Enhances retinoic acid-induced differentiation of HL-60 leukemia cells. Suppresses migration and invasion of human breast cancer cells (IC50 = 250 nM which is also the IC50 for inhibition of cellular Src kinase activity in intact tumor cells)\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"25 MG","offer_id":57410870837588,"sku":"ABM146739-1","price":229.0,"currency_code":"GBP","in_stock":true},{"title":"5 MG","offer_id":57410870870356,"sku":"ABM146739-2","price":65.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI2122.png?v=1791103250","url":"https:\/\/www.abmium.com\/es\/products\/tribio-bosutinib-src-abl-kinase-inhibitor","provider":"ABMIUM","version":"1.0","type":"link"}