{"product_id":"tribio-6-thioguanine-anticancer-agent-downregulates-dnmt1","title":"6-Thioguanine, Anticancer agent; Downregulates DNMT1","description":"\u003cp\u003eAfter incorporation into DNA, it disrupts cytosine methylation by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo. It reactivates epigenetically silenced genes in acute lymphoblastic leukemia cells by facilitating proteasome-mediated degradation of DNA methyltransferase (DNMT1). Incorporates into DNA and induces double strand breaks which destabilize DNA structure resulting in cytotoxicity. Selectively kills BRCA2-defective tumors and overcomes PARP inhibitor resistance in a xenograft model. Anticancer and immunosuppressive activity\u003c\/p\u003e","brand":"TriBio Science","offers":[{"title":"100 MG","offer_id":57410870051156,"sku":"ABM146534-1","price":49.0,"currency_code":"GBP","in_stock":true},{"title":"1 G","offer_id":57410870083924,"sku":"ABM146534-2","price":180.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/TBI1282-1.png?v=1791103245","url":"https:\/\/www.abmium.com\/es\/products\/tribio-6-thioguanine-anticancer-agent-downregulates-dnmt1","provider":"ABMIUM","version":"1.0","type":"link"}